Conolidine is often a organic alkaloid derived within the bark in the tropical shrub Tabernaemontana divaricata, also called crepe jasmine. This shrub was historically used in Chinese, Ayurvedic, and Thai medication, and is common for its potent suffering-relieving Qualities.Szpakowska et al. also studied conolidone and its action on the ACKR3 rece